COVID-19 has underlined that spatial inequality is relevant—and costly—everywhere: not only in developing countries. The pandemic has exposed sharp inequalities in prosperous cities, such as New York and San Francisco, as well as in slums and informal settlements in developing countries such as Kenya and Iran. This paper presents the results of a rapid appraisal carried out in May 2020. It surveys how existing urban inequalities have played out in practice, how spatial inequality has shaped the repercussions of COVID-19, and how housing-related program and community responses have helped close—or exacerbated—these gaps. It also outlines the opportunities and prospects for longer term reforms.